The fully 3D nature of the game yields a different style of gameplay from the traditional fighting game. Players are able to not only move forward, backward, sidestep, and jump but also to fly away to a safe distance or speed dash in for close combat. The players could stay close range for a more traditional experience, go long range and volley and dodge shots from each other, or play cat and mouse as one person continually moves across the room and the other speed dashes after them. The game also has the buttons dedicated to a specific limb instead of level of strength. This makes it a more intuitive control with the four face buttons grafted to the limbs and the shoulder buttons used for dodging, flying, and your basic long range attack. Bio F.R.E.A.K.S. offers several gameplay modes. The standard Arcade Mode which allows you to battle in a series of one-on-one battles against the other A.I. operated characters of the game, including the two bosses. The also standard Vs Mode where you can battle one-on-one against another person. There is also a Practice Mode so you can learn the controls of the game.